
Central United States Vacation Packages
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to CA $1,096 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Central United States Vacation
When it's time to set off on your next unforgettable adventure, a vacation package to Central United States is the answer. From this destination's friendly locals to all the other incredible things it's renowned for, there's a lot to discover. With so much to see and do on a trip to Central United States, it can be difficult to know where to begin. Kick off your travels in New York at Times Square and Central Park — two leading attractions here. Another great city worthy of a spot on your itinerary is Orlando. Don't miss Universal Studios Florida and Orlando International Premium Outlets. From the moment you book your Central United States vacation to when you return home, Expedia has your back every step of the way.
Top Central United States Vacation Deals

La Banque Hotel
Reviewed on Jan 26, 2026

Hampton Inn & Suites Houston Heights I-10
Reviewed on Jan 20, 2026

1 Hotel Nashville
Reviewed on Jan 12, 2026

Cooper Hotel Conference Center & Spa
Reviewed on Feb 6, 2026
Where to stay in Central United States

Downtown Chicago
The heart of the Midwest’s glittering metropolis has many offerings, from shopping and dining to parks, museums and exciting contemporary public art.
Central United States Hotel Deals

Congress Plaza Hotel
Great a+++
Reviewed on Feb 1, 2026

Hilton Chicago
Some of the nicest people you'll ever meet! Excellent location for a Bears game stay, walking distance to Soldier Field.
Reviewed on Feb 1, 2026

Embassy Suites by Hilton Chicago Downtown River North
Yes room was spotless
Reviewed on Feb 4, 2026
Discover the most popular places to visit in Central United States

River Walk
River Walk is just one of the places to see in San Antonio, so why not enjoy the other things to explore during your travels? Discover the acclaimed theater scene and shops in this walkable area.

Mall of America
You can browse for souvenirs when you visit Mall of America, a favorite shopping spot in Bloomington. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

Wrigley Field
Tour the iconic grounds and catch a game March through September at Chicago’s beloved baseball stadium.
Frequently asked questions
Explore a world of travel with Expedia
- Hotels near Mississippi River
- B&B in Ozarks
- Cabin Rentals in Ozarks
- Chalets in Ozarks
- Adults Only Resorts & in Ozarks
- All Inclusive Resorts and in Ozarks
- Beach Hotel Hotels in Ozarks
- Bluegreen Resorts in Ozarks
- Boutique Hotels in Ozarks
- Cheap Hotels in Ozarks
- Hotels & Resorts for Couples in Ozarks
- Family Hotels in Ozarks
- Golf Hotels in Ozarks
- Historic Hotels in Ozarks
- Honeymoon Resorts and in Ozarks
- Hotels with Free Parking in Ozarks
- Lgbt Friendly Hotels in Ozarks
- Lake Hotels in Ozarks
- Luxury Hotels in Ozarks
- Mountain Hotels in Ozarks
- Pet-Friendly Hotels in Ozarks
- Romantic Hotels in Ozarks
- Spa Hotels in Ozarks
- Waterpark Hotels in Ozarks
- Ozarks Hotels
- Motels in Ozarks
- Vacation Homes in Ozarks
- Resorts in Ozarks
- Treehouses in Ozarks
- B&B in Southeast Iowa
- Americinn Hotels in Southeast Iowa
- Luxury Hotels in Southeast Iowa
- Pet-Friendly Hotels in Southeast Iowa
- Romantic Hotels in Southeast Iowa
- Southeast Iowa Hotels












